Respiratory
Respiratory weakness can develop at any stage of disease progression and may cause shortness of breath, fatigue, impaired quality of life and somnolence. Dyspnoea is caused by weakened respiratory muscles – intercostals, diaphragm and abdominal muscles. read more
Swallowing
Dysphagia eventually affects about two thirds of people with motor deurone disease. It is caused by weakness and paralysis of the lips, facial muscles, tongue, larynx and pharynx resulting from affected trigeminal, facial, glossopharyngeal, vagus, accessory and hypoglossal nerves. read more
Communication
Dysarthria (impairment of speech production) is caused by weakness and paralysis of the lips, facial muscles, tongue, larynx, and pharynx resulting from affected trigeminal, facial, glossopharyngeal, vagus, accessory and hypoglossal cranial nerves. read more
Movement and joints
The degeneration of upper motor (UMN) and lower motor (LMN) neurons, leads to progressive weakness of bulbar, limb, thoracic and abdominal muscles (Andersen and others 2007) causing muscle weakness, stiffness and immobility. read more
Cognition
Fronto-temporal cognitive changes have been associated with MND. read more
Emotional lability
Upper motor neurone involvement is associated with pseudobulbar affect or emotional lability. read more
Fatigue
Fatigue (tiredness) is a common symptom of MND. It is caused by a number of factors. read more
Insomnia
Some people with MND experience disturbed sleep and morning fatigue. read more