Antioxidants
Orrell and others 2007
There is insufficient evidence of efficacy of individual antioxidants, or antioxidants in general, in the treatment of people with amyotrophic lateral sclerosis. While there is no substantial clinical trial evidence to support their clinical use, there is no clear contraindication.
Ciliary neurotrophic factor (CNTF)
Bongioanni and others 2004 (updated 2009)
Ciliary neurotrophic factor treatment had no significant effect on amyotrophic lateral sclerosis progression. At high concentrations, several side effects were observed.
Recombinant human insulin-like growth factor I (rhIGF-I)
Mitchell and others 2007
The available randomised placebo controlled trials do not permit a definitive assessment of the clinical efficacy of rhIGF-I on ALS. Future trials should include survival as an outcome measure.
